Figure-5

Figure 5. Calcium-analogue (Mn2+)-enhanced MR images of the rat brains show enhancement of tumor after 1 hour. First column shows coronal sections of a single representative MR image of normal pituitary enhancement at baseline and 1 and 11 hours postinjection (small black thick arrow). Other columns show coronal sections of each individual subject with pituitary adenoma. Adenomas of individual subjects show clear enhancement at 1 hour postinjection (large black arrow, middle row), which continues to increase for 11 hours (large black arrow, bottom row) and allows superior delineation of the tumor/brain border over nonenhanced baseline images. Right column in Rat 2 shows an FDG-PET scan of tumor glucose metabolism. Single arrows (white on MR imaging, thin black on PET) indicate regions of high glucose metabolism correlating with high calcium influx. Double arrows (white on MR imaging, black on PET) indicate low glucose metabolism and calcium influx in the area of necrosis. (Cross, Anzai, Maravilla, Minoshima et al.) Am J Neuroradiol. 2007;28:1865-1871.

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