Figure-1

Figure 1. Detection of autochthonous medulloblastoma in genetically engineered mice using optical imaging. A) Biophotonic images of tumor-free wild-type mouse (left) and ND2:SmoA1 mouse (right). Mice were injected with 0.2 mL of 10 Amol/L probe 1.5 d before imaging. Representative sample shown from five mice with similar results. B) Images of brains from the same mice following necropsy confirms signal from tumor. C) Histologic confirmation of medulloblastoma tumor. D) Confocal microscopy images from the same brains shown in (B) demonstrating the near absence of Cy5.5 signal in control and presence in medulloblastoma. (Olson, Zhang, Lee, et al.) Cancer Res 2007;67:6882-6888.

Click to view full-size image…