Clinical Science

Clinical Science

 

The Clinical Science group is comprised of physicians/researchers with backgrounds in cardiology, radiology, neurosurgery, and vascular surgery, and is directed by Thomas Hatsukami, MD, and Hunter Underhill, MD. The fundamental goal of this group is to apply high-resolution imaging techniques to address the following issues:

a. validation of new imaging methods, using histology as the gold standard
b. prospective clinical studies to test hypotheses on the mechanisms of atherosclerosis progression and regression
c. assessment of novel risk factors and biomarkers for the progression of atherosclerosis
d. evaluation of the efficacy of pharmacological intervention on the morphology and composition of atherosclerotic lesions

Figure 1.

Figure 1

Kaplan–Meier survival estimates of the proportion of patients remaining free of ipsilateral cerebrovascular events out of all patients with (lower curve) and without (upper curve) intraplaque hemorrhage. 'IPH' indicates intraplaque hemorrhage.
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Figure 2.

Figure 2

Kaplan–Meier survival estimates of the proportion of patients remaining free of ipsilateral cerebrovascular events out of all patients with (lower curve) and without (upper curve) a thin or ruptured fibrous cap.
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Figure 3.

Figure 3

Representative T1-weighted images of the progression of atherosclerosis with intraplaque hemorrhage in the right carotid artery. Each column presents matched cross-sectional locations in the carotid artery from the baseline MR image (A) and the MR image obtained 18 months later (B). The lumen area decreased in size and the wall area increased for each section at the second examination. 'CCA' indicates the common carotid artery; 'Bif,' bifurcation; 'ICA,' internal carotid artery; and 'ECA,' external carotid artery.

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