Anna Naumova, PhD

Anna Naumova, Ph.D.

Anna graduated from the Tomsk State University, Russia, in 1995 with an M.S. in biology. She obtained her PhD in Biology in 1999 from the Institute of Cardiology, Tomsk, Russia. For her dissertation, she used human papillary muscles and isolated Langerdorff-perfused rat hearts to investigate the mechanisms of cardioprotective and antiarrithmic effects of the natural plant extracts and pharmaceutical substances. Anna started a postdoctoral fellowship at Johns Hopkins University (Baltimore, MD) in 2002, where she studied cardiac metabolism and function using ECG-triggered 1H MRI and spatially localized 31P MR spectroscopy in wild type, transgenic and infarct operated mice.  In 2005 Anna joined the Vascular Imaging laboratory to the University of Washington (Seattle, WA). Her current research focuses on the investigation of stem cell transplantation benefits to alleviate function of infarcted heart.  Anna is developing the gene reporter system to study transplanted cells non-invasively by MRI.

Recent publications:

Naumova AV, Weiss RG, Chacko VP.  Regulation of Murine Myocardial Energy Metabolism During Adrenergic Stress Studied by In Vivo Phosphorus-31 NMR Spectroscopy. Am J Physiol Heart Circ Physiol  2003; 285(5): H1976-1979.

Naumova AV, Chacko VP, Ouwerkerk R, Stull L, Marban E, Weiss RG. Xanthine Oxidase Inhibitors Improve Energetics and Function Following Infarction in the Failing Mouse Heart. Am J Physiol Heart Circ Physiol 2006; 290: H837-H843.

Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Xu C, Hassanipour M, Police S, O'Sullivan C, Collins L, Minami E, Gill E.A, Ueno S, Yuan C, Gold J, Murry CE.  Delivery of Human Embryonic Stem Cell Cardiomyocytes in Pro-Survival Factors Enhances the Function of Infarcted Hearts.  Nature Biotech 2007, 25: 1015-1024.

Naumova AV, Reinecke H, Yarnykh V, Deem J, Yuan C, Murry CE.  Ferritin Overexpression for Noninvasive MRI-Based Tracking of Stem Cells Transplanted into the Heart. Journal for Molecular Imaging, 2010, 9 (4): 201-210.

Fernandes S, Naumova AV, Zhu WZ, Laflamme MA, Gold J, Murry CE.  Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats.   Journal of Molecular and Cellular Cardiology, 2010, 49: 941-949.